Complementary information
> This page contains information on recently submitted papers and will be updated in real time.
Confidential Information(s)
October 2025:
We are planning to move from IBDM to the MMG (INSERM U1251) before the end of 2025. The rederivation of our mouse lines is almost complete, and almost all lines have arrived at the MMG mouse facility or will arrive in the coming weeks. Our physical move should occur around November, and we are in the middle of organizing it. Meanwhile, we still have a few experimental cohorts to process at IBDM before december.
The team at MMG will be composed of me, Charline Ytier (AFM-Telethon fellowship, 2nd year PhD student), Clara David (1st year PhD student, Fellowship ED568). We will be helped by Pierre Perrin (Research engineer, IE), who is already helping us a lot.
My cancer treatment in 2025 was quite heavy until this summer, which slowed me down more than expected. While I focus on priorities related to the move, I’m also working on manuscripts. Here is an update on pending paper submissions: 1) The paper on Fat1/FAPs is close to ready (latest version below). The preprint will be posted on biorxiv in October 2025, and submitted. 2) The preprint 09/2022 was in fact never submitted (initially because of a cancer recurrence in 2023, and later because it didn’t make it back to my priority list). I plan to submit it right after the Fat1/FAP paper. 3) We have made progress with our new work with AAVs/CRISPR/dCas9 approach, and are also preparing a manuscript, which we will be preparing for submission in 2026 (first author Charline Ytier). Charline has prepared a poster for the AFM young researcher symposium on July 4th, and was awarded the Best Poster Prize.
Manuscripts ready for submission (Confidential)
Preprint : PA Ferracci & F. Helmbacher. Fat1 deletion enhances Fibro-adipose infiltrations induced by glycerol injury in skeletal muscle. (submission pending). PDF (provisory, almost complete). 21/10/2025 (replaces v1 from 07/10)
Will be updated when ready, and posted on biorxiv.
Manuscripts Submitted/under revision/Revised
I will only add preprints here when I am the lead senior author (unless a preprint was posted on biorXiv)
Preprint: Nathalie Caruso, Angela K Zimmermann, Tarana Nigam, Karelia Lipson, Françoise Helmbacher. An intragenic FAT1 regulatory element deleted in muscular dystrophy patients drives muscle and mesenchyme expression during development. Biorxiv (09/2022), September 17 | doi: 10.1101/2022.09.14.507898 | PDF |
Manuscripts Accepted/in press
papers are transfered below once published
Recently published
Published in 2024: Review article: Marcelo Flores-Opazo, Daniel Kopinke, Françoise Helmbacher, Rodrigo Fernández-Verdejo, Mauro Tuñón-Suárez, Gordon S. Lynch, and Osvaldo Contreras. Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling. Molecular Aspects of Medicine (2024), June, 101277. | PDF | PMID : 38788527 | published 23/05/2024
Accepted & Published: Rui Li, Jingchen Shao, Young-June Jin, Haruya Kawase, Yuting Ong, Kerstin Troidl, Qi Quan, Lei Wang, Remi Bonnavion, Astrid Wietelmann, Françoise Helmbacher, Michael Potente, Johannes Graumann, Nina Wettschureck, Stefan Offermanns. Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2. Nature Communications, (2023) April 08 | PDF | PMID: 37031213 |
Accepted & Published: Françoise Helmbacher. Astrocyte-intrinsic and extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina. Development (2022), January 20. | DOI: 10.1242/dev.192047 | PDF: FAT1-RETINA (last submitted version) | see also biorxiv preprint (2020) |
Accepted & Published: Francoise Helmbacher#, Sigmar Stricker#. Tissue cross talks governing limb muscle development and regeneration (Review article). Seminars in Cell and Developmental Biology, (2020), June 7. (#: co-corresponding).
-Available online 07/06/2020. (Helmbacher & Stricker 2020)
Accepted & Published : Ievgenia Pastushenko, Federico Mauri, Yura Song, Florian de Cock, Bob Meeusen, Benjamin Swedlund, Francis Impens, Delphi Van Haver, Matthieu Optiz, Manuel Thery, Yacine Bareche, Gaelle Lapouge, Marjorie Vermeersch, Yves-Rémi Van Eycke, Cédric Balsat, Christine Decaestecker, Youri Sokolow, Sergio Hassid, Beatriz Agreda-Moreno, Luis Rios-Buceta, Pedro Jaen, Pedro Redondo, Ramon Sieira-Gil, Nicky D’Haene, Virginie Moers, Milena Rozzi, Jeremy Blondeau, Sophie Lemaire, Samuel Scozzaro, Christine Dubois, David Pérez-Moraga, Isabelle Salmon, Christos Sotiriou, Francoise Helmbacher and Cédric Blanpain. Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis. Nature, (2021) 21 January | PMID: 33328637 |
Accepted & Published: Emily J. Lodge, Paraskevi Xekouki, Tatiane S. Silva, Cristiane Kochi, Carlos A. Longui, Fabio Faucz, Alice Santambrogio, James L. Mills, Nathan Pankratz, John Lane, Dominika Sosnowska, Tina Hodgson, Amanda L. Patist, Philippa Francis-West, Francoise Helmbacher, Constantine Stratakis, Cynthia Andoniadou. Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development. JCI Insight, (2020) Oct 27 |PMID: 33108146 | PDF |
– Submitted on 04/11/2019 – Revised 21/09/2020 – Accepted 15/10/2020 – Online 27/10/2020
Publication list
Available at the following links:
Scopus Author ID: 6506307667 | orcid.org/0000-0001-6822-1246 |Google scholar profile |
helmbacherlab.org 