May 2024
Paper acceptance day (13/05) 😊🎉. Stay tuned for novelties on the publication front.
Mars 2024
After having postponed it for way too long, and having wasted university approvals obtained in 2006 and 2011, I finally made obtaining my habilitation to direct researches (HDR) the priority of 2024. The date of my long due HDR defense has been fixed to 21/06/2024 (Amphi 12, 14h00, Luminy Campus).
October 2023
An apology for the lack of updates recently. We are excited to move back to the main building before the end of this month.
Among other long due updates, we were thrilled to be awarded an incentive action grant by the MarMaRa (Marseille Maladies Rares) Institute from Aix-Marseille University, to develop, in mice and in human IPS cells (in collaboration with F. Magdinier, MMG), a CRISPR/AAV-based method to block fibro-adipogenic differentiation in muscle pathologies.
Besides this, I was promoted CRHC at the CNRS, effective since April 2023 (and retroactive as of 10/2022). On a personal side, I’ve had two CT-scans in a row concluding complete remission after a 2023 recurrence.
April 2023
Congrats to our collaborators Rui Li & al from the lab of Stefan Offermanns at the Max Planck Institute for Heart and Lung Research, for a great paper showing that FAT1 controls YAP/TAZ degradation via the E3 ligase MIB2 during angiogenesis. DOI: 10.1038/s41467-023-37671-x
September 2022
Happy to share our new preprint “An intragenic FAT1 regulatory element deleted in muscular dystrophy patients drives muscle and mesenchyme expression during development”.
This is a long due follow up of our past discovery of FSHD-associated Copy number variants deleting a putative FAT1 enhancer (Caruso et al., Plos Genetics 2013). We have explored this possibility by investigating the transcriptional activity of this putative enhancer in vivo.
- Nathalie Caruso, Angela K. Zimmermann, Tarana Nigam, Celine Becker, Karelia Lipson, Françoise Helmbacher. “An intragenic FAT1 regulatory element deleted in muscular dystrophy patients drives muscle and mesenchyme expression during development” Biorxiv (2022), September 17 | doi: 10.1101/2022.09.14.507898 | PDF
January 2022
I’m delighted to share that the manuscript “Astrocyte-intrinsic and extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina” is now published in Development (2022) | doi:10.1242/dev.192047 | PDF |
This study uncovers astrocyte-intrinsic and extrinsic Fat1 activities that influence astrocyte migration polarity, proliferation and maturation, the disruption of which impacts retinal vascular development and maintenance of vascular architecture.
See all NEWs
helmbacherlab.org 