Publications

2023

  • Rui Li, Jingchen Shao, Young-June Jin, Haruya Kawase, Yuting Ong, Kerstin Troidl, Qi Quan, Lei Wang, Remi Bonnavion, Astrid Wietelmann, Françoise Helmbacher, Michael Potente, Johannes Graumann, Nina Wettschureck, Stefan Offermanns. Endothelial FAT1 inhibits angiogenesis by controling YAP/TAZ protein degradation via E3 Ubiquitin ligase MIB2. Nature Communications (2023) April 08 | PDF | PMID: 37031213 |

2022

  • Nathalie Caruso, Angela K. Zimmermann, Tarana Nigam, Celine Becker, Karelia Lipson, Françoise Helmbacher. “An intragenic FAT1 regulatory element deleted in muscular dystrophy patients drives muscle and mesenchyme expression during development” Biorxiv (2022), September 17 | doi: 10.1101/2022.09.14.507898 | PDF |
  • Françoise Helmbacher. “Astrocyte-intrinsic and extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina” Development (2022), January 20 | doi:10.1242/dev.192047 | PDF | PMID: 35050341 |

2021

  • Ievgenia Pastushenko, Federico Mauri, Yura Song, Florian de Cock, Bob Meeusen, Benjamin Swedlund, Francis Impens, Delphi Van Haver, Matthieu Opitz, Manuel Thery, Yacine Bareche, Gaelle Lapouge, Marjorie Vermeersch, Yves-Rémi Van Eycke, Cédric Balsat, Christine Decaestecker, Youri Sokolow, Sergio Hassid, Alicia Perez-Bustillo, Beatriz Agreda-Moreno, Luis Rios-Buceta, Pedro Jaen, Pedro Redondo, Ramon Sieira-Gil, Jose F. Millan-Cayetano, Onofre Sanmatrtin, Nicky D’Haene, Virginie Moers, Milena Rozzi, Jeremy Blondeau, Sophie Lemaire, Samuel Scozzaro, Veerle Janssens, Magdalena De Troya, Christine Dubois, David Pérez-Morga, Isabelle Salmon, Christos Sotiriou, Francoise Helmbacher & Cédric Blanpain. Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis. Nature, (2021) January 21 | PMID: 33328637 | Epub 2020 Dec 16.

2020

  • Emily J Lodge, Paraskevi Xekouki, Tatiane S Silva, Cristiane Kochi, Carlos A Longui, Fabio R Faucz, Alice Santambrogio, James L Mills, Nathan Pankratz, John Lane, Dominika Sosnowska, Tina Hodgson, Amanda L Patist, Philippa Francis-West, Francoise Helmbacher, Constantine Stratakis,  Cynthia L Andoniadou. Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development. JCI Insight, (2020) Oct 27 |PMID: 33108146 | PDF |
  • Francoise Helmbacher#, Sigmar Stricker#. Tissue cross talks governing limb muscle development and regeneration (Review article). Seminars in Cell and Developmental Biology, (2020), June 7 |PMID: 32517852 | #: co-corresponding | PDF: Helmbacher & Stricker 2020 |
  • Preprint: Helmbacher, F. Fat1 regulates astrocyte maturation and angiogenesis in the retina. BioRxiv preprint (revised/accepted 13/12/2021, in press, see 2022)

2019

  • Jones M., Lingampally A., Dilai S., Shrestha A., Stripp B., Helmbacher F., Chen, C., Chao, C.M., Bellusci S. Characterization of Etv4GFP and Etv5RFP reporter lines in the context of fibroblast growth factor 10 signalling during mouse embryonic lung development. Frontiers in Genetics (2019), 14 March | PMID: 30923534 | doi : 10.3389/fgene.2019.00178 |

2018

  • Petitpré, Wu H, Sharma A, Tokarska A, Fontanet P, Wang Y, Helmbacher F, Yackle K, Silberberg G, Hadjab S, & Lallemend F. Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system. Nature Communications (2018) Sep 12;9(1):3691. | PMID: 30209249 | doi: 10.1038/s41467-018-06033-3 | F1000 |

2016

  • Lamballe F, Toscano S, Conti F, Arechederra M, Baeza N, Figarella-Branger D, Helmbacher F, Maina F. Coordination of signalling networks and tumorigenic properties by ABL in glioblastoma cells. Oncotarget (2016)

2015

  • Fan Y, Richelme S, Avazeri E, Helmbacher F, Dono R, and Maina F. Tissue-specific gain of RTK signalling uncovers selective cell vulnerability during embryogenesis. PLOS Genetics (2015) September 22 | PMID : 26393505 | DOI: 10.1371/journal.pgen.1005533 |
  • Mazdak Bagherie-Lachidan, Antoine Reginensi, Hitisha P. Zaveri, Daryl A. Scott, Françoise Helmbacher and Helen McNeill. Stromal Fat4 acts non-autonomously with Dachsous1/2 to restrict the nephron progenitor pool. Development (2015) june 26 | PMID: 26116661 |
    doi: 10.1242/dev.122648 |
  • Mariot V, Roche S, Hourdé C, Portilho D, Sacconi S, Puppo F, Rameau P, Caruso N, Delezoide AL, Desnuelle C, Bessières B, Collardeau S, Feasson L, Maisonobe T, Magdinier F, Helmbacher F., Mouly V, Butler-Browne G. Dumonceaux J. Correlation between low FAT1 expression and early affected muscle in FSHD. Annals of Neurology (2015) MAY 28 | DOI: 10.1002/ana.24446 | PMID: 26018399 |
  • Puppo F., Dionnet E., Gaillard MC., Gaildrat P., Castro C., Vovan C., Bertaux K., Bernard R., Attarian S., Goto K., Nishino I., Hayashi Y., Magdinier F., Krahn, M., Helmbacher, F., Bartoli, M, and Levy, N. Identification of variants in the 4q35 gene FAT1 in patients with a Facioscapulohumeral dystrophy (FSHD)-like phenotype. Human Mutation (2015) 23 Jan | PMID : 25615407 | DOI: 10.1002/humu.22760

2014

  • Caruso N., Herberth B., Lamballe F., Arce-Gorvel V., Maina F., and Helmbacher F. Plasticity versus specificity in RTK signalling modalities for distinct biological outcomes in motor neurons. BMC Biology (2014) 12:56 | PMID:25124859 | doi:10.1186/s12915-014-0056-6 |
  • Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet AM, Tissir F. Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nat. Neuroscience (2014) Aug 10. | PMID: 25108913 | doi:10.1038/nn.3784.

2013

  • Caruso N, Herberth B, Bartoli M, Puppo F, Dumonceaux J, Zimmermann A, Denadai S, Lebossé M, Roche S, Geng L, Magdinier F, Attarian S, Bernard R, Maina F, Levy N, Helmbacher F. Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy. PLoS Genet. (2013) Jun;9(6):e1003550. | PMID: 23785297 | doi: 10.1371/journal.pgen.1003550 |

2012

  • Charoy C, Nawabi H, Reynaud F, Derrington E, Bozon M, Wright K, Falk J, Helmbacher F, Kindbeiter K, Castellani V. gdnf Activates Midline Repulsion by Semaphorin3B via NCAM during Commissural Axon Guidance. Neuron. (2012) Sep 20;75(6) | PMID: 22998873 | doi:
    10.1016/j.neuron.2012.08.021 | Highlighted in F1000 

2011

  • Lamballe F., Genestine M., Caruso N., Arce V., Richelme S., Helmbacher F.§ and Maina F.§ Pool-specific regulation of motor neuron survival by neurotrophic support. J Neurosci. (2011) Aug 3;31(31):11144-58.
    | PMID: 21813676 | doi: 10.1523/JNEUROSCI.2198-11.2011 | § equal contribution, co-corresponding authors.
  • Genestine M., Caricati E., Fico A., Richelme S., Hassani H., Lamballe F., Panzica G., Pettmann B., Helmbacher F., Raoul C., Maina F.* and Dono R.* Enhanced neuronal Met signalling levels in ALS mice delay disease onset. Cell Death Dis. (2011) Mar 17;2:e130. | PMID: 21412276 | doi:
    10.1038/cddis.2011.11 |

2010

  • Gascon E, Gaillard S, Mallapert P Liu Y, Rodat-Despoix L, Samokhalov I, Delmas P, Helmbacher F, Maina F, Moqrich A. HGF-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J Neurosci. (2010) Sep 15;30(37):12414-12423. | PMID: 20844136 | doi: 10.1523/JNEUROSCI.3135-10.2010 |

2006

  • Kramer E*, Knott L*, Su F, Dessaud E, Krull CE, Helmbacher F*, and Klein R*. Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor axon pathway selection in the limb. Neuron (2006). April 6, 50(1):35-47. | PMID: 16600854 | doi: 10.1016/j.neuron.2006.02.020 | (*equal contributions). Highlighted in F1000

2003

  • Helmbacher F, Dessaud E, Arber S, Delapeyriere O, Henderson CE, Klein R and Maina F. Met Signaling Is Required for Recruitment of Motor Neurons to PEA3-Positive Motor Pools. Neuron (2003) 39, 767-77. | PMID: 12948444 | doi: 10.1016/S0896-6273(03)00493-8 |

2001

  • Maina, F, Pante, G, Helmbacher, F, Andres, R, Porthin, A, Davies, AM, Ponzetto, C and Klein, R. Coupling Met to specific pathways results in distinct developmental outcomes. Molecular Cell (2001) 7, 1293-306. | PMID: 11430831 | doi: 10.1016/S1097-2765(01)00261-1  | F1000 |
  • Yokoyama, N., Romero, M. I., Cowan, C. A., Galvan, P., Helmbacher, F., Charnay, P., Parada, L. F. and Henkemeyer, M. Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron (2001)  29, 85-97. | PMID : 11182083 | doi :10.1016/S0896-6273(01)00182-9 |
  • Adams, R, Diella, F, Hennig, S, Helmbacher, F, Deutsch, U and Klein, R. The cytoplasmic domain of the ligand EphrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell (2001) 104, 57-69. | doi : 10.1016/S0092-8674(01)00191-X | PMID : 11163240 |

2000

  • Helmbacher, F, Schneider-Maunoury, S, Topilko, P, Tiret, L and Charnay, P. Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons. Development (2000) 127, 3313-24. | PMID : 10887087 | view at publisher | F1000 |

1998

  • Helmbacher, F., Pujades, C., Desmarquet, C., Frain, M., Rijli, F. M., Chambon, P. and Charnay, P. Hoxa1 and Krox-20 synergize to control the development of rhombomere3. Development (1998) 125, 4739-48. | PMID : 9806922 |

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Non Peer-reviewed

2018